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Structural Biology

Most of ETC’s drug discovery projects have a strong element of structural biology. This is crucial if successful rational drug design, hit to lead and lead optimisation campaigns are to be performed.  The cornerstone of ETC’s structural biology capabilities is its expertise in protein structure determination by NMR spectroscopy.  Apart from determining structure, the technique is also used to analyse protein dynamics, protein-protein interactions and SAR (structure activity relationships).

 

ETC has access to state-of-the-art NMR instrumentation internally (400 MHz) and at the National University of Singapore and Nanyang Technological University (600 MHz and 700 MHz).  Our researchers have extensive expertise in purification, co-expression of protein complexes and specific amino acid labeling of target proteins. The availability of this technology enables ETC to perform fragment-based screening providing an additional source of hits at the front end of the drug discovery process.

 

Protein crystallography also plays a major role in ETC’s drug discovery projects.  Our scientists work closely with the crystallography unit in BSF (Biopolis Shared Facility) which has highly automated screening facilities to identify and optimize the ideal crystallization conditions of our protein targets.  We also collaborate with the local structural biology community from other research institutes and universities.